Phleboviruses and the Type I Interferon Response

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Phleboviruses and the Type I Interferon Response

The genus Phlebovirus of the family Bunyaviridae contains a number of emerging virus species which pose a threat to both human and animal health. Most prominent members include Rift Valley fever virus (RVFV), sandfly fever Naples virus (SFNV), sandfly fever Sicilian virus (SFSV), Toscana virus (TOSV), Punta Toro virus (PTV), and the two new members severe fever with thrombocytopenia syndrome vi...

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Type I interferon (IFN) signaling leads to transcription and translation of key IFN-stimulated genes (ISGs), whose protein products exhibit anti-tumorigenic, anti-viral, and immunomodulatory functions [1-3]. These responses are triggered by the interaction of type I IFNs (IFNα, IFNβ, IFNω) with a unique cell surface receptor composed by two subunits: IFNα receptor 1 (IFNAR1) and IFNAR2 [1-3]. A...

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Type I interferon (IFN) activation and its subsequent effects are important in the response to viral infections. Here we show that human astroviruses (HAstVs), which are important agents of acute gastroenteritis in children, induce a mild and delayed IFN response upon infecting CaCo-2 cells. Although IFN-β mRNA is detected within infected cells and supernatant from infected cells show antiviral...

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The family Bunyaviridae contains more than 350 viruses that are distributed throughout the world. Most members of the family are transmitted by arthopods, and several cause disease in man, domesticated animals and crop plants. Despite being recognized as an emerging threat, details of the virulence mechanisms employed by bunyaviruses are scant. In this article we summarise the information curre...

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ژورنال

عنوان ژورنال: Viruses

سال: 2016

ISSN: 1999-4915

DOI: 10.3390/v8060174